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Restaging after Neoadjuvant Treatment

The accuracy of restaging gastric cancer after neoadjuvant chemotherapy decreases considerably. EUS has less than 50% accuracy for both T and N restaging, and similarly disappointing results have been reported for post-treatment staging with CT.349 However, the use of preoperative clinical staging to assess response to neoadjuvant chemoradiation may correlate well with both overall and disease-free survival.350 Restaging is therefore primarily used to rule out distant metastasis as part of the assessment for surgical resectability.