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The 4th International Molecular Pathological Epidemiology (MPE) Meeting is a meeting open to research community around the world, with free registration. This is a part of the ongoing International MPE Meetings Series. To advance integrative molecular and population-level health science and address the unique research challenges specific to the field of MPE requires bringing together experts in various fields including molecular pathology, epidemiology, biostatistics, bioinformatics, and nutritional and environmental sciences. This effort of integrating seemingly divergent fields can lead to a greater understanding of heterogeneity of the pathogenic process, and the impact of environmental, dietary, lifestyle, and genetic factors and their interactions on pathogenic processes. Brainstorming and discussion fostered by the MPE Meeting will lead to the development of new methodologies to address the unique research questions and challenges in this emerging field. This unique meeting can provide an unprecedented opportunity for interdisciplinary collaboration and integration of multiple diverse fields.